Roket IM/IV Injection 30mg/ml

✔️ Uses of Roket IM/IV Injection 30mg/ml

Treatment of moderate to severe pain.

✔️ How does Roket IM/IV Injection 30mg/ml work?

Ketorolac works by inhibiting prostaglandin synthesis through the reduction of cyclooxygenase enzyme activity.

✔️ Side Effects of Roket IM/IV Injection 30mg/ml

Common side effects include headache, somnolence, dyspepsia, GI pain, and nausea, while less common effects consist of diarrhea, dizziness, pruritus, edema, increased blood urea nitrogen (BUN), constipation, purpura, increased serum creatinine, drowsiness, hypertension, among others. Potentially fatal side effects may include anaphylaxis, severe skin reactions, myocardial infarction, stroke, and GI bleeding.

✔️ Quick Suggestions:

• You have been prescribed Roket IM/IV Injection 30mg/ml to relieve pain and inflammation.
• Take it as per the dose and duration prescribed by your doctor. Long-term use may lead to serious complications such as stomach bleeding and kidney problems.
• It may cause dizziness, drowsiness, or visual disturbances. Use caution while driving or doing anything that requires concentration.
• Avoid consuming alcohol while taking Roket IM/IV Injection 30mg/ml as it can cause excessive drowsiness and increase your risk of stomach problems.
• Inform your doctor if you have a history of heart disease or stroke.
• Your doctor may regularly monitor your kidney function, liver function, and levels of blood components if you are taking this medicine for long-term treatment.

✔️ Indication

During Roket IM/IV Injection 30mg/ml treatment, it is advisable to refrain from smoking. The most commonly reported side effects of Roket IM/IV Injection 30mg/ml may include indigestion, drowsiness, headache, sweating, dizziness, nausea, vomiting, or pain at the injection site. If any of these symptoms worsen or persist, consult your doctor for guidance.

✔️ Pharmacology

The non-steroidal anti-inflammatory medication ketorolac tromethamine is a powerful painkiller (NSAID). It works by preventing prostaglandin formation by inhibiting the cyclooxygenase enzyme system. At its analgesic dose, it has a minor anti-inflammatory action.

✔️ Dosage & Administration of Roket IM/IV Injection 30mg/ml

Adult Dosage:

• Oral Administration for Adults with Moderately Severe Acute Pain (Short-term, less than 5 days): Initiate with parenteral therapy. If necessary, oral administration may follow, with an initial dose of 20 mg after IV or IM therapy, then 10 mg every 4-6 hours, not exceeding 40 mg per day.
• IV Administration: A single dose of 30 mg or 30 mg every 6 hours, with a maximum of 120 mg per day.
• IM Administration: A single dose of 60 mg or 30 mg every 6 hours, with a maximum of 120 mg per day.
• Elderly Patients: Reduced dosages compared to adults, with careful monitoring.
• Duration of therapy should not exceed 5 days.

Child Dosage: Not established for children under 2 years. For children aged 2-16 years, a single dose of 0.5 mg/kg IV/IM is given, not exceeding 15 mg. Multiple doses of 0.5 mg/kg IV/IM every 6 hours can be administered for a maximum of 5 days.

Renal Dosing: Contraindicated in severe renal impairment. In cases of moderate renal impairment (with moderately elevated serum creatinine), use 50% of the recommended dosage, not exceeding 60 mg per day for IM/IV administration.

✔️ Interaction

Ketorolac may reduce the effects of antihypertensives such as ACE inhibitors or angiotensin II receptor antagonists (AIIA). It carries an increased risk of renal toxicity when used with ACE inhibitors and diuretics. Interaction with aspirin or other NSAIDs may lead to heightened adverse effects. Hallucinations may occur when combined with fluoxetine, thiothixene, or alprazolam. Potentially fatal interactions include an increased risk of GI bleeding with warfarin and heightened toxicity of methotrexate (MTX) and lithium. Concurrent use with probenecid can elevate plasma concentrations.

✔️ Contraindications

Avoid in cases of hypersensitivity to aspirin or other NSAIDs, asthma, hypovolemia, dehydration, postoperative high risk of bleeding, history of peptic ulcer or coagulation disorders, nasal polyps, angioedema, bronchospasm, during labor, moderate to severe renal impairment, GI bleeding, cerebrovascular bleeding, as prophylactic analgesic before surgery, during pregnancy, and lactation.

✔️ Pregnancy & Lactation

Ketorolac is categorized as C during pregnancy, but it transitions to D in the third trimester as it may cause premature closure of the ductus arteriosus.

✔️ Precautions & Warnings

Special precautions are advised for elderly patients, those weighing less than 50 kg, individuals with hepatic dysfunction, and heart failure, or those prone to reduced blood volume or renal blood flow. Monitor renal function closely. Avoid use during lactation due to drug excretion in breast milk with multiple doses.

✔️ Storage Conditions